Model Fitting and Simulation for Drug Release Kinetics and PK/PD

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Documentation for package ‘pkpd.Release’ version 0.1.0

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first_order_release First-Order Drug Release Kinetic Model
higuchi_release Higuchi Drug Release Kinetic Model
hixson_crowell_model Hixson-Crowell Drug Release Kinetic Model
korsmeyer_peppas_model Korsmeyer-Peppas Drug Release Kinetic Model
ld50_model Lethal Dose 50 (LD50) Pharmacodynamic Model
logistic_4pl 4PL Logistic Dose-Response Model (Emax/Imax)
logistic_5pl 5PL Logistic Dose-Response Model (Emax/Imax, Asymmetric)
michaelis_menten Michaelis-Menten Kinetics (Linear Form) with Inhibition Comparison
michaelis_menten_nl Michaelis-Menten Kinetics (Nonlinear Form) with Inhibition Comparison
non_compartmental Non-Compartmental Analysis (NCA) of Plasma Concentration-Time Data (Linear Form)
non_compartmental_nl Non-Compartmental Analysis (NCA) of Plasma Concentration-Time Data (Nonlinear Form)
one_compartment_iv_bolus One-Compartment IV Bolus Pharmacokinetic Model (Linear)
one_compartment_iv_bolus_nl One-Compartment IV Bolus Pharmacokinetic Model (Nonlinear)
one_compartment_oral One-Compartment Oral Pharmacokinetic Model (Linear, First-Order Absorption)
one_compartment_oral_nl One-Compartment Oral Pharmacokinetic Model (Nonlinear, First-Order Absorption)
sigmoid_emax Sigmoid Emax (Stimulatory Hill Model) for Dose-Response Analysis
sigmoid_imax Sigmoid Imax (Inhibitory Hill Model) for Dose-Response Analysis
td50_model Toxic Dose 50 (TD50) Pharmacodynamic Model
two_compartment_iv_bolus Two-Compartment IV Bolus Pharmacokinetic Model (Linear)
two_compartment_iv_bolus_nl Two-Compartment IV Bolus Pharmacokinetic Model (Nonlinear)
weibull_model Weibull Drug Release Kinetic Model
zero_order_release Zero-Order Drug Release Kinetic Model